The algorithm for Minimization of Metabolic Adjustment (MOMA) generates predictions of flux distribution for perturbed metabolic networks. The method is described in D. Segre', D. Vitkup and G.M. Church Proc. Natl. Acad. Sci. USA (2002), 99(23), 15112-15117 .
The in silico E. coli reconstruction we are using is derived from work done in the group of Bernhard Palsson, at UCSD. In particular, see J. Edwards and B.O. Palsson, Proc. Natl. Acad. Sci. USA (2000) 97, 5528-33. We acknowledge Jeremy Edwards and Bernhard Palsson for their help.
This site was built with the help of Wayne Rindone and Suzanne Clewley. Many thanks to Dat Nguyen for help with QP.
For comments or questions, please contact:
Daniel Segre', dsegre[at]genetics.med.harvard.edu